DEVELOPMENT AND VALIDATION OF NOMOGRAM TO PREOPERATIVELY PREDICT INTRAOPERATIVE CEREBROSPINAL FLUID LEAKAGE IN ENDOSCOPIC PITUITARY SURGERY: A RETROSPECTIVE COHORT STUDY

BackgroundPituitary adenomas (PAs) are the most common tumor of the sellar region.PA resection is the preferred treatment for patients with clear indications for surgery.Intraoperative cerebrospinal fluid (iCSF) leakage is a major complication of PA resection surgery.Risk factors for iCSF leakage have been studied previously, but a predictive nomog

Imidacloprid is a neonicotinoid neurotoxin that remains widely used worldwide and persists in the environment, resulting in chronic exposure to non-target insects.To accurately map dose-dependent effects of such exposure across taxa, toxicological assays need to assess relevant modes of exposure across indicator species.However, due to the difficul

Massively parallel sequencing of cell-free, maternal plasma DNA was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies.Here, we Toy Trucks report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps

We present Switchers a hydrodynamic model for a thin spherical shell of active nematic liquid crystal with an arbitrary configuration of defects.The active flows generated by defects in the director lead to the formation of stable vortices, analogous to those seen in confined systems in flat geometries, which generate effective dynamics for four +1